Metastatic Secondary Fibrosarcoma of Bone Responsive to Repeated Courses of Ifosfamide and Associated With Hypoglycemia. (2003)

• Record Type: Journal Article
• Authors: Bouttell, Elaine S.; Rodger, N. Wilson; Bramwell, Vivien H. C.
• Is Part Of: Sarcoma. Volume 7:Number 2(2003)
• Page Start: 81
• Page End: 85
• Publication Date: 2003
• Subjects: Sarcoma -- Periodicals; 616.994
• DOI: 10.1080/13577140310001607329
• Languages: English
• ISSNs: 1357-714X

Abstract

Abstract : We present a case of a 40-year-old man with secondary fibrosarcoma of bone, arising from a non-ossifying fibroma. He subsequently developed metastatic disease that responded to four successive chemotherapy courses, the last three using the same dose/schedule of single agent ifosfamide. Eventual rapid progression of a huge intra-abdominal mass was associated with the syndrome of extrapancreatic tumour hypoglycemia (EPTH). The clinicopathological behaviour of fibrosarcoma of bone, and the mechanism of EPTH are discussed.