Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression. Issue 3 (2004)

• Record Type: Journal Article
• Authors: Merendino, Rosaria Alba; Di Pasquale, Giuseppe; De Luca, Filippo; Di Pasquale, Laura; Ferlazzo, Edoardo; Martino, Gabriella; Palumbo, Maura Carmela; Morabito, Fortunato; Gangemi, Sebastiano
• Is Part Of: Mediators of inflammation. Volume 13:Issue 3(2004)
• Page Start: 205
• Page End: 207
• Publication Date: 2004
• Subjects: Moderate-severe depression -- fractalkine -- Macrophage inflammatory protein-1 alpha -- Serum; Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1080/09511920410001713484
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : MODERATE-severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein-1 alpha (MIP-1α) are, respectively, members of CX3C and C-C chemokines, and both are involved in recruiting and activating mononuclear phagocytes in the central nervous system. We analysed the presence of FKN and MIP-1α in sera of untreated MSD patients and healthy donors. High FKN levels were observed in all MSD patients as compared with values only detectable in 26% of healthy donors. MIP-1α was measurable in 20% of patients, while no healthy donors showed detectable chemokine levels. In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease.