Placental findings in non-hypertensive term pregnancies and association with future adverse pregnancy outcomes: a cohort study. (15th December 2018)

• Record Type: Journal Article
• Authors: Hauspurg, Alisse; Redman, Emily K.; Assibey-Mensah, Vanessa; Tony Parks, W.; Jeyabalan, Arun; Roberts, James M.; Catov, Janet M.
• Is Part Of: Placenta. Volume 74(2019)
• Page Start: 14
• Page End: 19
• Publication Date: 2018-12-15
• Subjects: Preeclampsia -- Preterm birth -- Small for gestational age -- Decidual vasculopathy -- Placental pathology -- Adverse pregnancy outcomes; PEC preeclampsia -- PTB preterm birth -- SGA small for gestational age -- APO adverse pregnancy outcome -- MVM maternal vascular malperfusion lesions -- MOMI Magee Obstetric Medical and Infant database; Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2018.12.008
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: Introduction: Women with adverse pregnancy outcomes (APOs) have excess risk of later life cardiovascular disease (CVD) perhaps related to an underlying high-risk vascular phenotype. We sought to determine if placental evidence of maternal malperfusion in uncomplicated pregnancies is associated with an increased risk of APOs in subsequent pregnancies. Methods: 536 women with more than one delivery and an initial uncomplicated pregnancy with placental pathology examination between 2008 and 2012 were included. APOs (small for gestational age, preterm delivery, or preeclampsia) were identified for each delivery. Multivariable log-binomial regression was used to estimate the risk of an APO in a subsequent pregnancy associated with MVM lesions in index pregnancy with adjustment for covariates. Results: Placental pathology from the initial pregnancy was compared between women with no APO in any pregnancy (-APO/-APO; n = 403) and women with an initial uncomplicated pregnancy and a subsequent adverse outcome (-APO/+APO; n = 133). Women with MVM lesions had an increased risk of an APO in a subsequent pregnancy relative to women with no MVM lesions after adjusting for covariates (aOR = 1.61; 95%CI = 1.06–2.46). Decidual vasculopathy was found in 13/133 (9.8%) of -APO/+APO women compared with 16/403 (4.0%) of -APO/-APO women, with an adjusted odds ratio of 2.51 (95% CI = 1.31–4.80). Discussion: MVM lesions found in placentas in uncomplicated pregnancies are associated with an increased risk of an adverse outcome in a subsequent pregnancy. Placental evidence of vascular malperfusion could offer a novel approach to risk stratification for subsequent pregnancy complications and perhaps future CVD. Highlights: Maternal vascular malperfusion lesions found commonly in uncomplicated pregnancies. Decidual vasculopathy associated with future risk of adverse pregnancy outcomes. Placental lesions may provide additional insight into future pregnancy risk.