Narrow Band Imaging with Magnification Endoscopy for Celiac Disease: Results from a Prospective, Single-Center Study. (6th August 2013)

• Record Type: Journal Article
• Authors: De Luca, L.; Ricciardiello, L.; Rocchi, M. B. L.; Fabi, M. T.; Bianchi, M. L.; de Leone, A.; Fiori, S.; Baroncini, D.
• Other Names: Aabakken Lars Academic Editor.
• Is Part Of: Diagnostic and therapeutic endoscopy. Volume 2013(2013)
• Publication Date: 2013-08-06
• Subjects: Endoscopy -- Periodicals; Endoscopie; Endoscopy; Endoscopy -- Periodicals; Electronic journals; Periodicals; 616.07545
• DOI: 10.1155/2013/580526
• Languages: English
• ISSNs: 1070-3608

Abstract

Abstract : In celiac disease (CD), the intestinal lesions can be patchy and partial villous atrophy may elude detection at standard endoscopy (SE). Narrow Band Imaging (NBI) system in combination with a magnifying endoscope (ME) is a simple tool able to obtain targeted biopsy specimens. The aim of the study was to assess the correlation between NBI-ME and histology in CD diagnosis and to compare diagnostic accuracy between NBI-ME and SE in detecting villous abnormalities in CD. Forty-four consecutive patients with suspected CD undergoing upper gastrointestinal endoscopy have been prospectively evaluated. Utilizing both SE and NBI-ME, observed surface patterns were compared with histological results obtained from biopsy specimens using the k-Cohen agreement coefficient. NBI-ME identified partial villous atrophy in 12 patients in whom SE was normal, with sensitivity, specificity, and accuracy of 100%, 92.6%, and 95%, respectively. The overall agreement between NBI-ME and histology was significantly higher when compared with SE and histology (kappa score: 0.90 versus 0.46;P = 0.001 ) in diagnosing CD. NBI-ME could help identify partial mucosal atrophy in the routine endoscopic practice, potentially reducing the need for blind biopsies. NBI-ME was superior to SE and can reliably predict in vivo the villous changes of CD.