Intravenous Penicillin for Antenatal Syphilotherapy. Issue 1 (1993)

• Record Type: Journal Article
• Authors: Galan, Henry L.; Yandell, Paul M.; Knight, Alfred B.
• Is Part Of: Infectious diseases in obstetrics and gynecology. Volume 1:Issue 1(1993)
• Page Start: 7
• Page End: 11
• Publication Date: 1993
• Subjects: Generative organs, Female -- Infections -- Periodicals; Communicable diseases in pregnancy -- Periodicals; 618.142005
• DOI: 10.1155/S1064744993000031
• Languages: English
• ISSNs: 1064-7449

Abstract

Abstract : A 21 year old woman (G2 P0101 ) of 24 weeks gestation presented with syphilis of unknown duration. Sonography revealed fetal hydrops and placental thickening. Weekly intramuscular injections of 2.4 million U Bicillin for 3 weeks was initiated as recommended by the Centers for Disease Control. Repeat sonogram 1 week after starting treatment revealed increased ascites and a new pericardial effusion. Due to the worsening fetal condition, therapy was altered and the patient was admitted for IV penicillin. She received a continuous infusion of 18 million U penicillin G daily for 10 days. Serial sonograms showed improvement offetal ascites and pericardial effusion with 10 days of IV therapy, and complete resolution of hydrops was noted within 3 weeks. The fetus was born at term with no stigmata of congenital syphilis on newborn exam, and laboratory tests suggested adequate treatment in utero.