Antioxidants and mucosa protectives: realistic therapeutic options in inflammatory bowel disease?. Issue 3 (1998)

• Record Type: Journal Article
• Authors: Kruidenier, L.; Verspaget, H. W.
• Is Part Of: Mediators of inflammation. Volume 7:Issue 3(1998)
• Page Start: 157
• Page End: 162
• Publication Date: 1998
• Subjects: antioxidants -- butyrate -- Crohn's disease -- fatty acids -- fish oil -- inflammatory bowel disease -- reactive oxygen metabolites -- superoxide dismutase -- ulcerative colitis; Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1080/09629359891081
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : Oxidative damage is involved in the pathogenic process of idiopathic chronic inflammatory bowel disease. Although specific intervention in the oxidative cascade showed promising results in animal models and preliminary patient trials, the clinical efficacy of antioxidants still has to be established. Mucosa protection, for example by dietary fatty acids, seems to attenuate the intestinal inflammatory process as well but awaits definite clinical proof for the treatment of inflammatory bowel disease