Experimental and computational studies on the synthesis of diastereoselective natural-based Meldrum spiro dibenzofuran derivatives. (8th April 2019)

• Record Type: Journal Article
• Authors: Dastoorani, Parvaneh; Khalilzadeh, Mohammad A.; Khaleghi, Fatemeh; Maghsoodlou, Malek Taher; Kaminsky, Werner; Shokuhi Rad, Ali
• Is Part Of: New journal of chemistry. Volume 43:Number 17(2019)
• Page Start: 6615
• Page End: 6621
• Publication Date: 2019-04-08
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c9nj00766k
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Herein, a novel route to achieve chiral Meldrum spiro dibenzofuran derivatives was developed, which involved a 2, 2-dimethyl-1, 3-dioxane-4, 6-dione (Meldrum's acid)-mediated Knoevenagel reaction of substituted aryl halides, followed by a Diels–Alder reaction with euparin as a natural compound. Abstract : Herein, a novel route to achieve chiral Meldrum spiro dibenzofuran derivatives was developed, which involved a 2, 2-dimethyl-1, 3-dioxane-4, 6-dione (Meldrum's acid)-mediated Knoevenagel reaction of substituted aryl halides, followed by a Diels–Alder reaction with euparin as a natural compound. Various multi-substituted Meldrum spiro dibenzofuran derivatives with very high regio- and diastereoselectivity were obtained in excellent yields at room temperature without requiring column chromatography. The synthesized product was further investigated using density functional theory (DFT) to verify the theoretical–experimental reliability; for this purpose, some parameters, including formation energy, solvent energy, chemical hardness, electronic chemical potential, and electrophilicity, were calculated for these compounds in different solvents using the B3LYP/631G(d, p) level of theory. The results of these computations have provided evidence that using quantum-chemical calculations, it is possible to estimate the stability of each product.