Heat shock protein 70/alpha-fetoprotein epitope peptide induced specific immunity against hepatocarcinoma. Issue 5 (April 2019)

• Record Type: Journal Article
• Authors: Xu, Bing; Wang, Xiaoping; Ma, Xiaojun; Lin, Huanping
• Is Part Of: IOP conference series. Volume 490:Issue 5(2019)
• Publication Date: 2019-04
• Subjects: Materials science -- Periodicals; 620.1105
• DOI: 10.1088/1757-899X/490/6/062020
• Languages: English
• ISSNs: 1757-8981

Abstract

Abstract: To study anti-tumor immunity mechanism induced by a reconstructed peptide complex-heat shock protein 70 (HSP70) and alphafetop-rotein (AFP), Mic e were immunized with AFP peptide, HSP70 and HSP70-AFP peptide complex es respectively. The killing effects of IFN-γ, TNF-α, perforin, granzyme B and CD8 + T cells on H22 cells were detected in each group of CD8 + T cell culture supernatants and investigate theimmune effect of heat shock protein 70 (HSP70)-alpha-fetoprotein (AFP)epitope peptide complex on mouse H22 hepatoma cells.