Ferrocene‐Initiated Oxidative Cyclization of Benzaldehyde with Alkyne: New Strategy to Substituted Indenones. Issue 16 (10th April 2019)

• Record Type: Journal Article
• Authors: Feng, Yadong; Zhang, Hong; Yu, Yunliang; Yang, Lei; Cui, Xiuling
• Is Part Of: European journal of organic chemistry. Issue 16(2019)
• Page Start: 2740
• Page End: 2744
• Publication Date: 2019-04-10
• Subjects: Ferrocene -- Cyclization -- Radical reactions -- C–H activation -- Synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201900281
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A ferrocene‐initiated oxidative cyclization of benzaldehyde with alkyne was successfully developed as a novel strategy for direct access to substituted indenones in high yields. The commercially available and cheap ferrocene was employed as an initiator. This transformation could proceed smoothly with a low initiator loading (0.5 mol‐%) and provide the titled products up to 90 % yield with atom‐, step‐economy and good substrates tolerance. The indenones obtained would be important building blocks in organic synthesis. Abstract : A ferrocene‐initiated oxidative cyclization of benzaldehyde with alkyne was successfully developed as a novel strategy for the direct access to substituted indenones in high yields. The commercially available and cheap ferrocene was employed as an initiator.