A new diantheramide and a new cyclic peptide from the seeds of Vaccaria hispanica. (March 2015)

• Record Type: Journal Article
• Authors: Zheng, Meng-Fei; Ren, Hui; Luo, Ying; Dong, Li-Mei; Wang, Ling-Qiong; Zhou, Zhong-Yu; Tan, Jian-Wen
• Is Part Of: Phytochemistry letters. Volume 11(2015:Mar.)
• Page Start: 240
• Page End: 244
• Publication Date: 2015-03
• Subjects: Vaccaria hispanica -- Diantheramide -- Cyclic peptide -- α-Glucosidase inhibitor; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2015.01.007
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: A new diantheramide (1 ) and a new cyclic peptide (2 ) were isolated from V. hispanica . Their structures were elucidated by spectroscopic analysis and chemical means. Compounds1 and2 showed significant α-glucosidase inhibitory activity. Abstract: A new diantheramide, 4, 4′-dihydroxy-2′-methoxydianthramide (1 ), and a new cyclic peptide, named segelin I (2 ) were isolated from the seeds of Vaccaria hispanica . Their structures were elucidated by detailed spectroscopic analysis and chemical methods. Compounds1 and2 were revealed to show significantly in vitro α-glucosidase inhibitory activity with IC50 values of 0.080 ± 0.002 mM and 0.28 ± 0.002 mM, respectively, which were more potent than the reference compound acarbose (IC50 0.410 ± 0.001 mM).