A Novel Stimuli-Responsive Magnetite Nanocomposite as De Novo Drug Delivery System. Issue 4 (4th March 2019)

• Record Type: Journal Article
• Authors: Mozafari, Zahra; Massoumi, Bakhshali; Jaymand, Mehdi
• Is Part Of: Polymer-plastics technology and materials. Volume 58:Issue 4(2019)
• Page Start: 405
• Page End: 418
• Publication Date: 2019-03-04
• Subjects: ATRP -- cancer chemotherapy -- magnetite nanosystem -- smart drug delivery -- stimuli responsive; Polymers -- Periodicals; Polymerization -- Periodicals; Plastics -- Periodicals; Plastics; Polymerization; Polymers; Periodicals; 668
• DOI: 10.1080/03602559.2018.1471718
• Languages: English
• ISSNs: 2574-0881

Abstract

ABSTRACT: A novel stimuli-responsive magnetite nanocomposite as de novo drug delivery system for cancer chemotherapy is developed successfully through the incorporation of magnetite nanoparticles into PEG- b -(PNIPAAm- b -PAA)2 copolymer. The chemical structures of samples were characterized using FTIR and 1 H NMR spectroscopies. Furthermore, thermal property, morphology, size, and magnetic properties of the nanocomposite were investigated. The DOX loading and encapsulation efficiencies as well as stimuli-responsive drug release ability of the nanosystem were studied. As results, at pH 5.3 and temperature of 41°C the nanocomposite exhibited higher drug release values, which qualified it for cancer chemotherapy according to especial features of cancerous tissue. GRAPHICAL ABSTRACT: