Synthesis, characterization, swelling-deswelling properties of Novel nanoparticle-hydrogel containing core chitosan and their cyclohexanone-crosslinked counterparts. Issue 9 (13th June 2019)

• Record Type: Journal Article
• Authors: Bary, E. M. Abdel; Harmal, Ammar N.; Gouda, Moustafa A.
• Is Part Of: Polymer-plastics technology and materials. Volume 58:Issue 9(2019)
• Page Start: 992
• Page End: 1004
• Publication Date: 2019-06-13
• Subjects: Chitosan -- hydrogels -- swellability -- mannish base -- drug delivery; Polymers -- Periodicals; Polymerization -- Periodicals; Plastics -- Periodicals; Plastics; Polymerization; Polymers; Periodicals; 668
• DOI: 10.1080/03602559.2018.1542715
• Languages: English
• ISSNs: 2574-0881

Abstract

ABSTRACT: Novel Chitosan-cyclohexanone Mannich based hydrogel nanoparticles (CCMb 1-4) were prepare via the reaction of chitosan with different concentration of 2, 6-bis (piperidin-1-ylmethyl) cyclohexanone. 2HCl (1%, 5%, 10% and 15% wt/wt) at 70–80°C for 7 h. These hydrogels were subjected to equilibrium swelling studies at room temperature in solutions of pH 2, 4, 6 and 8. The (CCMb 1-4) showed maximum percent swellability at pH = 2.0. Furthermore, the swelling of the (CCMb 1-4) followed Fickian diffusion. This preliminary investigation of chitosan-based interpolymeric hydrogels showed that they may be exploited to expand the utilization of these systems in drug delivery applications. Graphical Abstract: