Dietary docosahexaenoic acid contributes to increased bone mineral accretion and strength in young female Sprague-Dawley rats. (May 2019)

• Record Type: Journal Article
• Authors: Farahnak, Zahra; Freundorfer, Marie Therese; Lavery, Paula; Weiler, Hope A.
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 144(2019)
• Page Start: 32
• Page End: 39
• Publication Date: 2019-05
• Subjects: Dose-response -- DHA -- Peak bone mass -- Growth; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2019.04.005
• Languages: English
• ISSNs: 0952-3278

Abstract

Highlights : Dietary DHA increased whole body BMC, along with lumbar spine and long bone. Whole body and lumbar spine aBMD and also vBMD were increased by dietary DHA. Dietary DHA contributes to PBM when consumed during and after sexual maturation. Higher doses of DHA do not provide further benefits for bone health. Abstract: Growing evidence suggests that docosahexaenoic acid (DHA: 22:6n-3) enhances bone mineral content (BMC) and bone mineral density (BMD) in adulthood and during aging, however the effects during and after sexual maturation are unclear. The aim of this study was to examine the dose-response of BMC, BMD and microarchitectural properties of bone to dietary DHA in healthy growing female rats during acquisition of peak bone mass (PBM). Female Sprague-Dawley rats ( n = 12/diet) were randomized to receive a control diet (AIN-93 M, 60 g soybean oil/kg diet) or an experimental diet containing 0.1, 0.4, 0.8 and 1.2% DHA (w/w of total diet) for 10 weeks. Dietary DHA increased the whole body, lumbar spine and long bone BMC compared to the control, in addition to higher aBMD and also BMD. Additionally, an increase in cortical bone microarchitecture parameters of lumbar spine as well as peak force were observed in dietary DHA diet groups. Dietary DHA contributes to PBM when consumed during and after sexual maturation, however higher doses of DHA do not provide further benefits.