Reciprocal interactions across and within multiple levels of monoamine and cortico-limbic systems in stress-induced depression: A systematic review. (June 2019)

• Record Type: Journal Article
• Authors: Lee, Eun-Hwa; Han, Pyung-Lim
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 101(2019)
• Page Start: 13
• Page End: 31
• Publication Date: 2019-06
• Subjects: Monoamines -- Cortico-limbic system -- Depression -- Stress -- Neural circuit activity -- Animal models; ACC anterior cingulate cortex -- AMY amygdala -- BLA basolateral amygdala -- CA1 Cornu Ammonis 1 -- CA3 Cornu Ammonis 3 -- CaMKII Ca2+/calmodulin-dependent protein kinase II -- CORT corticosterone -- CRST chronic restraint stress -- CSDS chronic social defeat stress -- C(U)MS chronic (unpredictable) mild stress -- DA dopamine -- DG dentate gyrus -- dHP dorsal hippocampus -- DOPAC 3, 4-dihydroxyphenylacetic acid -- DREADDs Designer Receptors Exclusively Activated by Designer Drugs -- DRN dorsal raphe nuclei -- DSM-V The Diagnostic and Statistical Manual of Mental Disorders-V -- dSTR dorsal striatum -- ERK extracellular signal-regulated kinases -- FST forced swim test -- GABA gamma-aminobutyric acid -- GLU glutamate -- HP hippocampus -- HVA homovanillic acid -- IL infralimbic cortex -- LC locus coeruleus -- LHb lateral habenula -- LTD long-term depression -- LTP long-term potentiation -- MDD major depressive disorder -- mPFC medial prefrontal cortex -- MSNs medium spiny neurons -- NA noradrenaline -- NAc nucleus accumbens -- NMDA N-methyl-D-aspartate -- OFC orbitofrontal cortex -- PL prelimbic cortex -- PVN paraventricular nucleus of the hypothalamus -- RMTg mesopontine rostromedial tegmental nucleus -- SIT social interaction test -- SPT sucrose preference test -- SSRI selective serotonin reuptake inhibitor -- STR striatum -- TST tail suspension test -- TTX tetrodotoxin -- vGluT3 vesicular glutamate transporter 3 -- vHP ventral hippocampus -- VP ventral pallidum -- vSTR ventral striatum -- vSub ventral subiculum -- VTA ventral tegmental area -- 5-HIAA 5-hydroxyindoleacetic acid -- 5-HT 5-hydroxytryptamine, serotonin -- 6-OHDA 6-hydroxydopamine; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2019.03.014
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Chronic stress changes neural activity of cortico-limbic regions and monoamine systems. Monoamine and non-monoamine systems are reciprocally interactive at multiple levels. Reshaping altered neural activity dynamics reverses depressive-like behaviors. Abstract: The monoamine hypothesis of depression, namely that the reduction in synaptic serotonin and dopamine levels causes depression, has prevailed in past decades. However, clinical and preclinical studies have identified various cortical and subcortical regions whose altered neural activities also regulate depressive-like behaviors, independently from the monoamine system. Our systematic review indicates that neural activities of specific brain regions and associated neural circuitries are adaptively altered after chronic stress in a specific direction, such that the neural activity in the infralimbic cortex, lateral habenula and amygdala is upregulated, whereas the neural activity in the prelimbic cortex, hippocampus and monoamine systems is downregulated. The altered neural activity dynamics between monoamine systems and cortico-limbic systems are reciprocally interwoven at multiple levels. Furthermore, depressive-like behaviors can be experimentally reversed by counteracting the altered neural activity of a specific neural circuitry at multiple brain regions, suggesting the importance of the reciprocally interwoven neural networks in regulating depressive-like behaviors. These results promise for reshaping altered neural activity dynamics as a therapeutic strategy for treating depression.