Association between chronic obstructive pulmonary disease and interleukins gene variants: A systematic review and meta-analysis. (May 2019)

• Record Type: Journal Article
• Authors: Ahmadi, Ali; Ghaedi, Hamid; Salimian, Jafar; Azimzadeh Jamalkandi, Sadegh; Ghanei, Mostafa
• Is Part Of: Cytokine. Volume 117(2019)
• Page Start: 65
• Page End: 71
• Publication Date: 2019-05
• Subjects: Interleukin -- Chronic obstructive pulmonary disease -- Variant -- Meta-analysis; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2019.02.003
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlights: Carriers of CC genotype for the IL6 -rs1800795 are at significantly risk for COPD. There is no association for IL1β gene variants and increased risk of COPD. IL1RN -rs2234663 and IL13 -rs1800925 are associated with risk of COPD development. Abstract: Interleukins are cytokines involved in systemic inflammation and immune system regulation. Many studies have investigated the association between common genetic variations in interleukin-coding genes and COPD susceptibility. In this study, a systematic review and meta-analysis was performed to evaluate the association between interleukin gene variations and COPD pathogenesis. Association studies were retrieved from PubMed and Google Scholar databases using the standard systematic search strategy. A total of 26 different studies evaluating eight polymorphisms in four interleukin genes were included in this study. In overall comparisons, IL1β-rs16944, -rs1143627, -rs1143634, IL13-rs20541 polymorphisms were found not to be associated with the increased risk for developing COPD. However, IL1RN-rs2234663 and IL13-rs1800925 showed a strong association with COPD. We showed that the CC genotype carriers of the IL6-rs1800795 are at significantly higher risk of developing COPD (OR = 1.31, 95% CI: 1.04–1.64, P = 0.01) compared to GG carriers. In case of IL6-rs1800796, individuals with CC and CG genotypes showed a lower risk to develop COPD (OR = 0.46, 95%CI: 0.32–0.66, P > 0.00). This updated meta-analysis strongly supports the association of IL1RN-rs2234663, IL6-rs1800795, -rs1800795 and IL13-rs1800925 variants with COPD.