Associations of medium and long chain omega-3 polyunsaturated fatty acids with blood pressure in Hispanic and non-Hispanic smokers and nonsmokers. (May 2019)

• Record Type: Journal Article
• Authors: Zehr, Kayla R.; Segovia, Allison; Shah, Meera; Walsh-Wilcox, Mary T.; Brumbach, Barbara H.; Anderson, Joe R.; Walker, Mary K.
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 144(2019)
• Page Start: 10
• Page End: 15
• Publication Date: 2019-05
• Subjects: Omega-3 index -- Blood pressure -- Docosahexaenoic acid -- Alpha-linolenic acid -- Hispanic -- Cigarette smoking; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2019.04.003
• Languages: English
• ISSNs: 0952-3278

Abstract

Highlights: The omega-3 index is significantly lower in smokers and Hispanics. Docosahexaenoic acid is significantly and inversely associated with blood pressure in smokers and nonsmokers. Alpha-linolenic acid is significantly and positively associated with blood pressure only in smokers. Summary: Epidemiology studies and clinical trials have shown that omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with blood pressure. We sought to determine the influence of cigarette smoking and Hispanic ethnicity on this association. Age- and sex-matched smokers and nonsmokers ( n = 98) 19–50 years old lacking cardiovascular disease were recruited. Systolic and diastolic blood pressure (SBP, DBP), heart rate, HbA1c, lipids, BMI, and RBC fatty acids were measured. The omega-3 index (percent eicosapentaenoic and docosahexaenoic acid, EPA+DHA, in RBCs) was significantly lower in smokers (Smokers: 3.19 ± 0.86%; Nonsmokers, 3.88 ± 1.05%, p = 0.001) and Hispanics (Hispanic 3.32 ± 0.93%; Non-Hispanic, 3.82 ± 1.03%, p = 0.006). DHA exhibited a significant inverse association with BP in both smokers and nonsmokers, while alpha-linolenic acid (ALA) exhibited a significant positive association with BP only in smokers. Multiple regression analyses showed that BMI, DHA, smoking status, and smoking status*ALA interaction significantly predicted SBP ( p < 0.0001, R 2 = 0.44) and DBP ( p < 0.0001, R 2 = 0.33), while ethnicity had no effect. The observed lower BP when DHA levels are high suggests a possible protective role of DHA on BP in normotensive smokers and nonsmokers. Additionally, the observed higher BP when ALA levels are high only in smokers suggests that ALA may influence the BP-lowering effects of chronic smoking.