Essential element Cu and non-essential element Hg exposures have different toxicological effects in the liver of large yellow croaker. (February 2019)

• Record Type: Journal Article
• Authors: Zeng, Lin; Ai, Chunxiang; Zhang, Jianshe; Zheng, Jialang
• Is Part Of: Marine pollution bulletin. Volume 139(2019)
• Page Start: 6
• Page End: 13
• Publication Date: 2019-02
• Subjects: CAT catalase -- Cu/Zn-SOD copper/zinc-superoxide dismutase -- IL-1β interleukin-1β -- IL-6 interleukin-6 -- iNOS nitric oxide synthase -- MTF-1 metal-responsive element-binding transcription factor-1 -- MTs metallothioneins -- NF-κB nuclear transcription factor κB -- Nrf2 NFE2-related nuclear factor 2 -- ROS reactive oxygen species -- TNF-α tumor necrosis factor-α; Metal exposure -- Oxidative stress -- Inflammatory response -- Larimichthys crocea; Marine pollution -- Periodicals; Marine Biology -- Periodicals; Water Pollution -- Periodicals; Mer -- Pollution -- Périodiques; Publications périodiques; Pollution des mers; Lutte antipollution; Electronic journals; 363.7394
• DOI: 10.1016/j.marpolbul.2018.12.029
• Languages: English
• ISSNs: 0025-326X

Abstract

Abstract: The objective was to compare the different effects of essential element Cu and non-essential element Hg on antioxidant and inflammatory responses in the liver of large yellow croaker Larimichthys crocea . Fish were exposed to Cu stresses (72 and 288 μg L −1 ) and Hg stresses (14 and 56 μg L −1 ) for 96 h. High-dose Cu increased metallothioneins (MTs) levels and immune defenses in response to elevated reactive oxygen species (ROS), but low-dose Cu had no effect on ROS. High-dose Hg reduced antioxidant and inflammatory responses, which contributed to the increment of ROS. MTs may be a suitable biomarker to assess Cu contamination, but no relationship was observed between MTs levels and Hg content. Furthermore, NFE2-related nuclear factor 2 (Nrf2) and nuclear transcription factor κB (NF-κB) were positively related to their respective target genes in the Cu-exposed groups. In conclusion, Cu and Hg induced some differences in antioxidant and inflammatory responses, which providing some novel insights into toxicological effects of Cu and Hg stresses. Highlights: We aim to compare the toxicological effects between Cu and Hg in Larimichthys crocea . Cu and Hg induced some differences in antioxidant and inflammatory responses. MTs may be a suitable biomarker to assess Cu contamination. No correlation was observed between MTs protein levels and Hg content. Nrf2 and NF-κB paralleled with their respective target genes in fish under Cu stress.