A novel carbocatalytic hydride transfer strategy for efficient reduction of structurally different aldehydes and ketones in water. Issue 7 (14th February 2019)

• Record Type: Journal Article
• Authors: Rai, Vijai K.; Mahata, Suhasini; Bhardiya, Smita R.; Shukla, Prashant; Rai, Ankita; Singh, Manorama
• Is Part Of: Tetrahedron letters. Volume 60:Issue 7(2019)
• Page Start: 524
• Page End: 529
• Publication Date: 2019-02-14
• Subjects: Bio-reduced graphene oxide -- Regioselective reduction -- Aldehydes -- Ketones -- Aqueous medium; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.01.019
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Reduced graphene oxide (rGO) is reported as mild and efficient catalyst for hydride transfer reaction. Chemo-/regioselective reduction of different aldehydes and ketones in water. The rGO was prepared by reducing graphene oxide using Tulsi leaf extract as bio-reductant. High yield, no by-product formation and no use of column chromatography for purification. Abstract: Reduced graphene oxide (rGO)–NaBH4 is reported as mild and efficient catalyst-system for chemo-/regioselective reduction of structurally different aliphatic, aromatic as well as α, β-unsaturated aldehydes and ketones in water. The rGO was prepared by reducing graphene oxide using Tulsi leaf extract as bio-reductant. Operational simplicity, ambient reaction condition, high yield of pure products (80–97%), no by-product formation, no use of column chromatography for purification are the salient features of the envisaged protocol. Furthermore, the recovered TRGO was recycled and reused for subsequent reductions up to five times without any loss in activity.