Synthesis, crystal structure and efficient SOD activity of transition compounds constructed with 5-aminoisophthalic acid ligand. (1st March 2019)

• Record Type: Journal Article
• Authors: Zhang, Kai-Yue; Zhang, Yuan-Hong; Wang, Ying; Xing, Yong-Heng; Sun, Li-Xian
• Is Part Of: Polyhedron. Volume 160(2019)
• Page Start: 247
• Page End: 254
• Publication Date: 2019-03-01
• Subjects: Superoxide dismutase -- SOD activity -- Metal compounds -- Crystal structure -- Synthesis; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2018.12.054
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Three new superoxide dismutase mimetics with perfect SOD activity were discovered. Their IC50 values were less than the internationally specified values (30 mg/L). Particular, the IC50 value of Cd-SOD is 2.7 mg/L. Highlights: Three new superoxide dismutase model compounds: [CoL(H2 O)]·2H2 O (1 ), [CdL(H2 O)]·H2 O (2 ) and [PbL] (3 ). Superoxide dismutase (SOD) activity. Relationship between structure and SOD activity. Abstract: Three new superoxide dismutase model compounds: [CoL(H2 O)]·2H2 O (1 ), [CdL(H2 O)]·H2 O (2 ) and [PbL] (3 ) were successfully synthesized by the reaction of a transition metal salt and 5-aminoisophthalic acid under hydrothermal conditions (L: 5-aminoisophthalic acid). The three compounds were characterized by elemental analysis, infrared spectroscopy, ultraviolet–visible spectroscopy, PXRD analysis and TG analysis. X-ray single crystal diffraction analysis showed that compounds2 and3 were 3D inorganic–organic framework structures while compound1 was a 2D structure. These simulations contained pores structures with maximum sizes of 4.08–14.67 Å. To further explore the functional properties of these compounds, we firstly analyzed their SOD activity, and the results demonstrated that they have different SOD activities. The IC50 values of the three mimics are much smaller than the international standard for SOD standards, demonstrating that these mimics have superior Reactive Oxygen Species resistance.