Mitochondrial UPR: A Double-Edged Sword. Issue 8 (August 2016)

• Record Type: Journal Article
• Authors: Tian, Ye; Merkwirth, Carsten; Dillin, Andrew
• Is Part Of: Trends in cell biology. Volume 26:Issue 8(2016)
• Page Start: 563
• Page End: 565
• Publication Date: 2016-08
• Subjects: UPRmt -- ATFS-1 -- OXPHOS -- mtDNA deletion -- mitochondrial heteroplasmy -- mitochondrial disease; Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2016.06.006
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : The mitochondrial unfolded protein response (UPR mt ) promotes the recovery of dysfunctional mitochondria. Surprisingly, UPR mt activation inadvertently maintains and propagates the deleterious mtDNA in a heteroplasmic Caenorhabditis elegans strain, with detrimental consequences. This study extends our understanding of the UPR mt and provides a possible therapeutic target for diseases associated with mtDNA mutations.