Nature and nurture: confluence of pathway determinism with metabolic and chemical serendipity diversifies Monascus azaphilone pigments. Issue 4 (28th November 2018)

• Record Type: Journal Article
• Authors: Chen, Wanping; Feng, Yanli; Molnár, István; Chen, Fusheng
• Is Part Of: Natural product reports. Volume 36:Issue 4(2019)
• Page Start: 561
• Page End: 572
• Publication Date: 2018-11-28
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/c8np00060c
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : This highlight maps111 congeners of Monascus azaphilone pigments on a unitary biosynthetic pathway and summarizes the causes for their diversity. Abstract : Covering: up to June 2018 Understanding the biosynthetic mechanisms that generate the astounding structural complexity and variety of fungal secondary metabolites (FSMs) remains a challenge. As an example, the biogenesis of the Monascus azaphilone pigments (MonAzPs) has remained obscure until recently despite the significant medical potential of these metabolites and their long history of widespread use as food colorants. However, a considerable progress has been made in recent years towards the elucidation of MonAzPs biosynthesis in various fungi. In this highlight, we correlate a unified biosynthetic pathway with the diverse structures of the111 MonAzPs congeners reported until June 2018. We also discuss the origins of structural diversity amongst MonAzPs analogues and summarize new research directions towards exploring novel MonAzPs. The case of MonAzPs illuminates the various ways that FSMs metabolic complexity emerges by the interplay of biosynthetic pathway determinism with metabolic and chemical serendipity.