Transcriptome Signature Reversion as a Method to Reposition Drugs Against Cancer for Precision Oncology. Issue 2 (March 2019)

• Record Type: Journal Article
• Authors: Koudijs, Karel K. M.; Terwisscha van Scheltinga, Anton G. T.; Böhringer, Stefan; Schimmel, Kirsten J. M.; Guchelaar, Henk-Jan
• Is Part Of: Cancer journal. Volume 25:Issue 2(2019)
• Publication Date: 2019-03
• Subjects: Drug repositioning -- gene expression -- molecular targeted therapy -- neoplasms -- precision medicine -- systems biology; Cancer -- Periodicals; 616.994005
• DOI: 10.1097/PPO.0000000000000370
• Languages: English
• ISSNs: 1528-9117

Abstract

Abstract : Abstract: Transcriptome signature reversion (TSR) has been hypothesized as a promising method for discovery and use of existing noncancer drugs as potential drugs in the treatment of cancer (i.e., drug repositioning, drug repurposing). The TSR assumes that drugs with the ability to revert the gene expression associated with a diseased state back to its healthy state are potentially therapeutic candidates for that disease. This article reviews methodology of TSR and critically discusses key TSR studies. In addition, potential conceptual and computational improvements of this novel methodology are discussed as well as its current and possible future application in precision oncology trials.