Deoxygenative cross-electrophile coupling of benzyl chloroformates with aryl iodides. Issue 17 (5th April 2019)

• Record Type: Journal Article
• Authors: Pan, Yingying; Gong, Yuxin; Song, Yanhong; Tong, Weiqi; Gong, Hegui
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 17(2019)
• Page Start: 4230
• Page End: 4233
• Publication Date: 2019-04-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob00628a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : We disclose herein a Ni-catalyzed benzyl C–O bond radical fragmentation/cross-electrophile coupling of benzyl chloroformates with aryl iodides to generate diaryl methane derivatives. Abstract : This work describes Ni-catalyzed cross-electrophile coupling of benzyl chloroformate derivatives with aryl iodides that generates a wide range of diaryl methane products. The mild reaction conditions merit the C–O bond radical fragmentation of benzyl chloroformates via halide abstraction or a single electron reduction by a Ni catalyst. This work offers a new substrate type for cross-electrophile couplings.