A multifunctional persistent luminescent nanoprobe for imaging guided dual-stimulus responsive and triple-synergistic therapy of drug resistant tumor cells. Issue 36 (17th April 2019)

• Record Type: Journal Article
• Authors: Su, Feng-Xia; Zhao, Xu; Dai, Cong; Li, Yu-Jie; Yang, Cheng-Xiong; Yan, Xiu-Ping
• Is Part Of: Chemical communications. Volume 55:Issue 36(2019)
• Page Start: 5283
• Page End: 5286
• Publication Date: 2019-04-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc01446b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel multifunctional persistent luminescent nanoprobe was fabricated for imaging guided dual-stimulus responsive and triple-synergistic therapy for multiple drug resistant tumor cells. Abstract : We report the design and fabrication of a multifunctional persistent luminescent nanoprobe for imaging guided dual-stimulus responsive and triple-synergistic therapy of drug resistant tumor. The integration of the dual-stimulus of an acidic microenvironment and laser irradiation with the triple-synergistic therapy of doxorubicin, photothermal and siRNA offers excellent therapeutic performance for drug resistant tumor cells with high specificity and little side effects.