The scientific evidence for the role of milk protein-derived bioactive peptides in humans: A Review. (August 2015)

• Record Type: Journal Article
• Authors: Nongonierma, Alice B.; FitzGerald, Richard J.
• Is Part Of: Journal of functional foods. Volume 17(2015)
• Page Start: 640
• Page End: 656
• Publication Date: 2015-08
• Subjects: Bioactive peptides -- Milk -- Human studies -- Bioavailability; A alanine -- ACE angiotensin converting enzyme -- ACP amorphous calcium phosphate -- ACPF amorphous calcium phosphate fluoride -- Ala alanine -- Arg arginine -- BAP bioactive peptide -- BCAA branched-chain amino acids -- BMI body mass index -- BP blood pressure -- C cysteine -- Ca calcium -- CCK cholecystokinin -- CK creatine kinase -- CMP caseinomacropeptide -- CMPA cow's milk protein allergy -- CN casein -- CNH casein hydrolysate -- CPP caseinophosphopeptides -- CVD cardiovascular disease -- Cys cysteine -- D aspartic acid -- DBP diastolic blood pressure -- DPP-IV dipeptidyl peptidase IV -- E glutamic acid -- EFSA European Food Safety Authority -- F phenylalanine -- Fe iron -- G glycine -- GI gastrointestinal transit -- GIP gastric inhibitory polypeptide -- GIT gastrointestinal transit -- GLP-1 glucagon-like peptide 1 -- Glu glutamic acid -- Gly glycine -- GSH glutathione -- H histidine -- hsCRP high-sensitivity C-reactive protein -- I isoleucine -- IgA immunoglobulin A -- IL-10 interleukin-10 -- IL-6 interleukin-6 -- IL-8 interleukin-8 -- Ile isoleucine -- ITF inulin type fructan -- K lysine -- L lysine -- LDH lactate dehydrogenase -- Leu leucine -- LF lactoferrin -- LTP lactotripeptides -- Lys lysine -- M methionine -- N asparagine -- P proline -- Phe phenylalanine -- PKU phenylketonuria -- ppm part per million -- Pro proline -- PYY peptide YY -- Q glutamine -- R arginine -- ROS reactive oxygen species -- S serine -- SBP systolic blood pressure -- SGID simulated gastrointestinal digestion -- Ser serine -- Ser(P) phosphorylated serine -- T threonine -- T2D type 2 diabetes -- TAC total antioxidant capacity -- TFCA true fractional Ca absorption -- Thr threonine -- TNF-α tumour necrosis factor-α -- Tr-1 type 1-regulatory T -- Trp tryptophan -- Tyr tyrosine -- V valine -- Val valine -- W tryptophan -- WHO World Health Organization -- WP whey protein -- WPC whey protein concentrate -- WPH whey protein hydrolysate -- WPI whey protein isolate -- Y tyrosine -- Zn zinc; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2015.06.021
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Milk proteins are a good source of bioactive peptides (BAPs). A limited number of BAPs have been reported in human biological fluids and tissues. Controversial results on the role of BAPs in human health have been reported. Low bioavailability and confounding factors may explain the controversial results. Abstract: Milk proteins are a good source of bioactive peptides (BAPs). BAPs can positively affect various health biomarkers in vitro . The role of milk protein-derived BAPs in humans was reviewed herein. To date, a limited number of BAPs have been identified in the gastrointestinal tract of humans and in the circulation at concentrations which may be sufficient to mediate in vivo bioactivity. While the outcomes of several human intervention studies have shown promising results, some studies have failed to demonstrate additional health benefits. This may be related to a low potency and bioavailability of the BAPs evaluated as well as confounding factors (i.e. genotype, health status and other sources of inter-individual variability). Universal guidelines for the evaluation of BAPs in humans such as adequately powered double-blind randomised clinical trials are needed.