Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Rozenberg, Robert; Mankowski, Robert; Loon, Luc; Langendonk, Janneke; Sijbrands, Eric; Meiracker, Anton; Stam, Henk; Praet, Stephan
• Is Part Of: European journal of medical research. Volume 21:Issue 1(2016)
• Page Start: 1
• Page End: 8
• Publication Date: 2016-12
• Subjects: Diabetes type 2 -- Hyperoxia -- Exercise -- Oxygen -- Dose; Medicine -- Research -- Periodicals; Clinical medicine -- Periodicals; 610.72
• DOI: 10.1186/s40001-015-0194-5
• Languages: English
• ISSNs: 2047-783X

Abstract

Abstract Objective The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % Wmax ) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min−1 ). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min−1 ); 18.5 ± 1.5 (5 L min−1 ); 21.7 ± 1.7 (10 L min−1 ); 24.0 ± 2.3 (15 L min−1 ). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions An SOF of 15 L min−1 appears to be more effective than 5 or 10 L min−1 . Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.