Gold nanostructure microelectrode arrays for in vitro recording and stimulation from neuronal networks. (25th March 2019)

• Record Type: Journal Article
• Authors: Koklu, Anil; Atmaramani, Rahul; Hammack, Audrey; Beskok, Ali; Pancrazio, Joseph J; Gnade, Bruce E; Black, Bryan J
• Is Part Of: Nanotechnology. Volume 30:Number 23(2019)
• Publication Date: 2019-03-25
• Subjects: microelectrode array -- gold nanostructures -- neural activity recordings -- electrical stimulation -- cortical neuronal networks; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/1361-6528/ab07cd
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: An ideal microelectrode array (MEA) design should include materials and structures which exhibit biocompatibility, low electrode polarization, low impedance/noise, and structural durability. Here, the fabrication of MEAs with indium tin oxide (ITO) electrodes deposited with self-similar gold nanostructures (GNS) is described. We show that fern leaf fractal-like GNS deposited on ITO electrodes are conducive for neural cell attachment and viability while reducing the interfacial impedance more than two orders of magnitude at low frequencies (100–1000 Hz) versus bare ITO. GNS MEAs, with low interfacial impedance, allowed the detection of extracellular action potentials with excellent signal-to-noise ratios (SNR, 20.26 ± 2.14). Additionally, the modified electrodes demonstrated electrochemical and mechanical stability over 29 d in vitro .