Poly(propylene fumarate)-based materials: Synthesis, functionalization, properties, device fabrication and biomedical applications. (July 2019)

• Record Type: Journal Article
• Authors: Cai, Zhongyu; Wan, Yong; Becker, Matthew L.; Long, Yun-Ze; Dean, David
• Is Part Of: Biomaterials. Volume 208(2019)
• Page Start: 45
• Page End: 71
• Publication Date: 2019-07
• Subjects: Poly(propylene fumarate) (PPF) -- Synthesis and crosslinking -- Resorbable bone scaffold -- Tissue engineering and drug delivery -- Regenerative medicine -- Stereolithography and cDLP 3D printing; 3D three dimensional -- AM additive manufacturing -- A-MSC adipocyte mesenchymal stem cells -- Sb2O3 antimony trioxide -- BAPO phenylbis(2, 4, 6-trimethylbenzoyl)-phosphine oxide -- BD 1, 4-butanediol -- bFGF basic fibroblast growth factor -- BMP-2 bone morphogenetic protein 2 -- BM-MSC bone marrow-derived mesenchymal stem cell -- BPO benzoyl peroxide -- cDLP continuous digital light processing -- Da Dalton -- DCC dicyclohexylcarbodiimide -- DCPD dicalcium phosphate dihydrate -- DEF diethyl fumarate -- DMT N, N-dimethyl-p-toluidine -- Dp penetration depth -- ƉM molecular mass distribution -- Ec critical exposure -- FGF-2 fibroblast growth factor -- F-SWNTs functionalized single-walled carbon nanotubes -- GRGD glycine–arginine–glycine–aspartic acid -- HAP hydroxyapatite -- HMB oxybenzophenone -- HUVECs human umbilical vein endothelial cells -- MA maleic anhydride -- MAPO monoacylphosphine oxide -- MBFs mineralized bone fibers -- MMA methylmethacrylate -- Mn number average molecular weight -- MPM propylene bis(hydrogen maleate) -- MRI magnetic resonance-guided implantation -- hMSCs human mesenchymal stem cells -- NVP n-vinyl pyrrolidone -- mPEGA methoxy poly (ethylene glycol) -- mPOSS methacryl-polyhedral oligomeric silsesquioxane -- MSTL microstereolithography -- Mw weight average molecular weight -- NHS N-hydroxysuccinimide -- OGP osteogenic growth peptide -- PCL polycarolactone -- PD 1, 2-propylene diol (PD) -- PEG poly(ethylene glycol) -- PEG-DMA poly(ethylene glycol)-dimethacrylate -- PF-DA propylene fumarate-diacrylate -- P(FA-co-DEG) poly(fumaric acid-co-diethylene glycol) -- PFP bis(2-hydroxypropyl fumarate) -- PLGA poly(DL-lactic-co-glycolic acid) -- PMMA poly(methyl methacrylate) -- PPF poly(propylene fumarate) -- PPF-co-PM poly(propylene fumarate)-co-(propylene maleate) -- P(FA-co-DEG) poly(fumaric acid-co-diethylene glycol) -- PVP poly(vinyl pyrrolidone) -- RGD arginine–glycine–aspartic acid -- rhBMP-2 recombinant human Bone morphogenetic protein -- ROP ring opening polymerization -- HMB 2-hydroxy-4-methoxybenzophenone -- Sb2O3 antimony trioxide -- SWNTs single-walled carbon nanotubes -- β-TCP beta-tricalcium phosphate -- TGF-β1 transforming growth factor beta 1 -- UV ultraviolet -- VEGF vascular endothelial growth factor -- TDI 2, 4-toluene diisocyanate -- ZnCl2 zinc chloride; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2019.03.038
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Poly(propylene fumarate) (PPF) is a biodegradable polymer that has been investigated extensively over the last three decades. It has led many scientists to synthesize and fabricate a variety of PPF-based materials for biomedical applications due to its controllable mechanical properties, tunable degradation and biocompatibility. This review provides a comprehensive overview of the progress made in improving PPF synthesis, resin formulation, crosslinking, device fabrication and post polymerization modification. Further, we highlight the influence of these parameters on biodegradation, biocompatibility, and their use in a number of regenerative medicine applications, especially bone tissue engineering. In particular, the use of 3D printing techniques for the fabrication of PPF-based scaffolds is extensively reviewed. The recent invention of a ring-opening polymerization method affords precise control of PPF molecular mass, molecular mass distribution ( Ɖ M ) and viscosity. Low Ɖ M facilitates time-certain resorption of 3D printed structures. Novel post-polymerization and post-printing functionalization methods have accelerated the expansion of biomedical applications that utilize PPF-based materials. Finally, we shed light on evolving uses of PPF-based materials for orthopedics/bone tissue engineering and other biomedical applications, including its use as a hydrogel for bioprinting. Graphical abstract: Image 1