A home calendar and recall method of last menstrual period for estimating gestational age in rural Bangladesh: a validation study. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Gernand, Alison; Paul, Rina; Ullah, Barkat; Taher, Muhammad; Witter, Frank; Wu, Lee; Labrique, Alain; West, Keith; Christian, Parul
• Is Part Of: Journal of health, population and nutrition. Volume 35:Issue 1(2016)
• Page Start: 1
• Page End: 9
• Publication Date: 2016-12
• Subjects: Last menstrual period -- Ultrasound -- Validation -- Bangladesh -- Gestational age -- Crown-rump length; Population -- Health aspects -- Periodicals; Nutrition disorders -- Prevention -- Periodicals; Preventive health services -- Periodicals; Families -- Health and hygiene -- Periodicals; Nutrition -- Developing countries -- Periodicals; Public health -- Developing countries -- Periodicals; Developing countries -- Periodicals; Preventive Health Services -- Periodicals; Developing countries -- Periodicals; Family Health -- Periodicals; Nutrition -- Periodicals; Nutrition Disorders -- prevention & control -- Periodicals; Santé publique -- Périodiques; Nutrition -- Périodiques; 614.4091724
• DOI: 10.1186/s41043-016-0072-y
• Languages: English
• ISSNs: 2072-1315

Abstract

Abstract Background The best method of gestational age assessment is by ultrasound in the first trimester; however, this method is impractical in large field trials in rural areas. Our objective was to assess the validity of gestational age estimated from prospectively collected date of last menstrual period (LMP) using crown-rump length (CRL) measured in early pregnancy by ultrasound. Methods As part of a large, cluster-randomized, controlled trial in rural Bangladesh, we collected dates of LMP by recall and as marked on a calendar every 5 weeks in women likely to become pregnant. Among those with a urine-test confirmed pregnancy, a subset with gestational age of <15 weeks (n = 353) were enrolled for ultrasound follow-up to measure CRL. We compared interview-assessed LMP with CRL gestational age estimates and classification of preterm, term, and post-term births. Results LMP-based gestational age was higher than CRL by a mean (SD) of 2.8 (10.7) days; differences varied by maternal education and preterm birth (P < 0.05). Lin's concordance correlation coefficient was good at ultrasound [0.63 (95 % CI 0.56, 0.69)] and at birth [0.77 (95 % CI 0.73, 0.81)]. Validity of classifying preterm birth was high but post-term was lower, with specificity of 96 and 89 % and sensitivity of 86 and 67 %, respectively. Results were similar by parity. Conclusions Prospectively collected LMP provided a valid estimate of gestational age and preterm birth in a rural, low-income setting and may be a suitable alternative to ultrasound in programmatic settings and large field trials. Trial registration ClinicalTrials.govNCT00860470