MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Li, Pei; Yang, Yang; Liu, Hui; Yang, An-Kui; Di, Jin-Ming; Tan, Guang-Mou; Wang, Hai-Feng; Qiu, Jian-Ge; Zhang, Wen-Ji; Jiang, Qi-Wei; Zheng, Di-Wei; Chen, Yao; Wei, Meng-Ning; Huang, Jia-Rong; Wang, Kun; Shi, Zhi; Ye, Jin
• Is Part Of: Journal of hematology & oncology. Volume 10:Issue 1(2017)
• Page Start: 1
• Page End: 4
• Publication Date: 2017-12
• Subjects: Laryngeal squamous cell carcinoma -- miR-194 -- Wee1; Hematology -- Periodicals; Oncology -- Periodicals; Blood -- Diseases -- Periodicals; 616.994
• DOI: 10.1186/s13045-017-0402-6
• Languages: English
• ISSNs: 1756-8722

Abstract

Abstract The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that miR-194 is significantly downregulated in LSCC tissues and cells, and overexpression of miR-194 inhibits the proliferation, migration, invasion, and drug resistance in LSCC cells. Moreover, Wee1 is identified as a novel direct target of miR-194. Ectopic expression of Wee1 at least in part overcomes the suppressive impacts of miR-194 on the malignant phenotypes of LSCC. Overall, our study provides new sights into the role of miR-194/Wee1 axis in LSCC and suggests a novel miR-194/Wee1-based clinical application for LSCC patients.