Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Jiang, Zhiwu; Deng, Manman; Wei, Xinru; Ye, Wei; Xiao, Yiren; Lin, Simiao; Wang, Suna; Li, Baiheng; Liu, Xin; Zhang, Gong; Lai, Peilong; Weng, Jianyu; Wu, Donghai; Chen, Haijia; Wei, Wei; Ma, Yuguo; Li, Yangqiu; Liu, Pentao; Du, Xin; Pei, Duanqing; Yao, Yao; Xu, Bing; Li, Peng
• Is Part Of: Journal of hematology & oncology. Volume 9:Issue 1(2016)
• Page Start: 1
• Page End: 5
• Publication Date: 2016-12
• Subjects: B-ALL -- Leukemia stem cell -- Heterogeneity -- Xenografts; Hematology -- Periodicals; Oncology -- Periodicals; Blood -- Diseases -- Periodicals; 616.994
• DOI: 10.1186/s13045-016-0310-1
• Languages: English
• ISSNs: 1756-8722

Abstract

Abstract The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized.