Lung‐Targeted Rnai Therapeutics: Lung‐Endothelium‐Targeted Nanoparticles Based on a pH‐Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer (Adv. Funct. Mater. 18/2019). (2nd May 2019)

• Record Type: Journal Article
• Authors: Abd Elwakil, Mahmoud M.; Khalil, Ikramy A.; Elewa, Yaser H. A.; Kusumoto, Kenji; Sato, Yusuke; Shobaki, Nour; Kon, Yasuhiro; Harashima, Hideyoshi
• Is Part Of: Advanced functional materials. Volume 29:Number 18(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-05-02
• Subjects: GALA targeting -- lung endothelium -- metastatic lung cancers -- pH‐sensitive lipid nanoparticles -- siRNA delivery systems; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201970121
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : Engineering nanocarrier systems for efficient small interfering RNA (siRNA) delivery requires advanced materials that can achieve specific cellular targeting together with efficient intracellular trafficking for reaching target sites in the cytosol. In article number1807677, Ikramy A. Khalil, Hideyoshi Harashima, and co‐workers use nanoparticles modified with the GALA peptide as targeted therapy for the lung endothelium, resulting in a robust gene knockdown. The nanoparticles are successfully applied for the regression of metastatic lung cancer.