Wet/Sono‐Chemical Synthesis of Enzymatic Two‐Dimensional MnO2 Nanosheets for Synergistic Catalysis‐Enhanced Phototheranostics. Issue 19 (28th March 2019)

• Record Type: Journal Article
• Authors: Tang, Wei; Fan, Wenpei; Zhang, Weizhong; Yang, Zhen; Li, Ling; Wang, Zhantong; Chiang, Ya‐Ling; Liu, Yijing; Deng, Liming; He, Liangcan; Shen, Zheyu; Jacobson, Orit; Aronova, Maria A.; Jin, Albert; Xie, Jin; Chen, Xiaoyuan
• Is Part Of: Advanced materials. Volume 31:Issue 19(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-03-28
• Subjects: nanozymes -- phototheranostics -- sono‐chemical modification -- two‐dimensional nanosheets -- wet‐chemical synthesis; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201900401
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: 2D nanomaterials have attracted broad interest in the field of biomedicine owing to their large surface area, high drug‐loading capacity, and excellent photothermal conversion. However, few studies report their "enzyme‐like" catalytic performance because it is difficult to prepare enzymatic nanosheets with small size and ultrathin thickness by current synthetic protocols. Herein, a novel one‐step wet‐chemical method is first proposed for protein‐directed synthesis of 2D MnO2 nanosheets (M‐NSs), in which the size and thickness can be easily adjusted by the protein dosage. Then, a unique sono‐chemical approach is introduced for surface functionalization of the M‐NSs with high dispersity/stability as well as metal‐cation‐chelating capacity, which can not only chelate 64 Cu radionuclides for positron emission tomography (PET) imaging, but also capture the potentially released Mn 2+ for enhanced biosafety. Interestingly, the resulting M‐NS exhibits excellent enzyme‐like activity to catalyze the oxidation of glucose, which represents an alternative paradigm of acute glucose oxidase for starving cancer cells and sensitizing them to thermal ablation. Featured with outstanding phototheranostic performance, the well‐designed M‐NS can achieve effective photoacoustic‐imaging‐guided synergistic starvation‐enhanced photothermal therapy. This study is expected to establish a new enzymatic phototheranostic paradigm based on small‐sized and ultrathin M‐NSs, which will broaden the application of 2D nanomaterials. Abstract : A 2D enzymatic MnO2 nanosheet, M‐NS, is developed by a novel one‐step wet‐chemical synthesis and followed by a unique sono‐chemical modification. The M‐NS, with a small and ultrathin morphology, exhibits intriguing glucose‐oxidase‐like catalytic activity and excellent phototheranostic performance. An effective photoacoustic‐imaging‐guided synergistic starvation‐enhanced photothermal therapy is successfully achieved, broadening the application of 2D nanomaterials in biomedicine.