CDK6 3'UTR polymorphisms alter the susceptibility to cervical cancer among Uyghur females. Issue 5 (4th March 2019)

• Record Type: Journal Article
• Authors: Aierken, Kailibinuer; Dong, Zhihong; Abulimiti, Tangnuer; Zhang, Yuanyuan; Abuduxikuer, Guzhalinuer; Tuerxun, Gulixian; Abudurexiti, Guligeina; Maimaitiaishan, Aziguli; Mijiti, Patiman; Abulizi, Guzhalinuer
• Is Part Of: Molecular genetics & genomic medicine. Volume 7:Issue 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-03-04
• Subjects: 3' untranslated region -- CDK6 gene -- cervical cancer risk -- single nucleotide polymorphisms -- Uyghur females; Medical genetics -- Periodicals; Genomics -- Periodicals; 616.042
• DOI: 10.1002/mgg3.626
• Languages: English
• ISSNs: 2324-9269

Abstract

Abstract: Aims: Cyclin dependent kinase 6 (CDK6) plays a crucial role in malignant tumor whereas less is reported in cervical cancer development. The aim of this study was to evaluate the effects of CDK6 3' untranslated region (3'UTR) polymorphisms on cervical cancer susceptibility among Uyghur females. Methods: The genotypes of the six CDK6 variants (rs8179, rs42032, rs42033, rs42034, rs42035, and rs42038) were identified among 306 cervical cancer cases and 310 healthy controls with the Agena MassARRAY platform. The associations of the candidate single nucleotide polymorphisms (SNPs) with the cervical cancer risk were evaluated under genetic models using conditional logistic regression analysis. Bioinformatics analysis was performed for SNP function prediction with the online databases. The expression differences between tumor tissues and normal cervix samples were also examined by Real‐time PCR. Results: CDK6 rs8179 and rs42033 were correlated to the decreased risk of cervical cancer in Uyghurs under the allele model (rs8179 and rs42033: OR = 0.60, 95% CI: 0.37–0.99, p = 0.043) and log‐additive model (rs8179 and rs42033: OR = 0.62, 95% CI: 0.38–1.00, p = 0.047). Rs8179, rs42032, and rs42033 were associated with susceptibility to high‐grade cervical cancer in different genetic models as well ( p < 0.05). Dataset‐based analysis also uncovered the potential effects of these significant SNPs. In addition, aberrant expression of CDK6 were detected in cervical tumors. Conclusions: Our results suggested the relationships between CDK6 3'UTR polymorphisms and cervical cancer pathogenesis, and the involvement of CDK6 in cervical cancer development among Uyghur females. Abstract : CDK6 is involved in the pathogenesis of cervical cancer. CDK6 variants reduce the susceptibility to cervical cancer in Uyghur females. Rs8179, rs42032 and rs42033 are new markers for cervical cancer early assessment.