Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks. Issue 5 (19th March 2019)

• Record Type: Journal Article
• Authors: Cirillo, Giuseppe; Curcio, Manuela; Spizzirri, Umile Gianfranco; Vittorio, Orazio; Valli, Emanuele; Farfalla, Annafranca; Leggio, Antonella; Nicoletta, Fiore Pasquale; Iemma, Francesca
• Is Part Of: Macromolecular materials and engineering. Volume 304:Issue 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-03-19
• Subjects: antioxidant polymers -- drug delivery -- dual stimuli‐responsive hydrogels -- pH -- temperature; Plastics -- Periodicals; Polymers -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1002/mame.201800728
• Languages: English
• ISSNs: 1438-7492

Abstract

Abstract: Multifunctional hydrogels based on chitosan–quercetin (CHITQ) conjugate are prepared by a thermo‐induced radical procedure in the presence of N ‐isopropylacrylamide (NIPAAm), acrylamide (AAm), and N, N ′‐methylenebis(acrylamide) (MEBA). At first, quercetin (Q) is grafted onto chitosan backbone with a functionalization degree of 275 mg of Q per gram of conjugate, as calculated by 1 H‐NMR analyses to impart antioxidant properties to the polysaccharide. Then, a pH and temperature sensitive hydrogel was obtained by involving CHITQ and NIPAAm in the polymerization reaction. The accessibility of phenolic moieties is modified in response to the hydrogel swelling/deswelling, as confirmed by antioxidant tests performed at different temperatures. Dual stimuli‐responsive hydrogels are proposed for the delivery of caffeine as model drug. The release profiles of caffeine depict a system particularly performing as on/off device at acidic pH with excellent applicability prospects. Abstract : Multifunctional hydrogels showing tunable antioxidant activity and responsiveness to pH and temperature modification are obtained by cross‐linking a chitosan–quercetin bioconjugate within an acrylic polymeric network. The antioxidant activity can be modulated via temperature modification, while both pH and temperature concur in controlling the release of loaded therapeutics.