12-hydroxy oleic acid impairs endothelium-dependent vasorelaxation. Issue 5 (4th March 2019)

• Record Type: Journal Article
• Authors: Bass, Virginia L.; Snow, Samantha; Soukup, Joleen; Schladweiler, Mette; Ghio, Andrew; Kodavanti, Urmila; Madden, Michael C.
• Is Part Of: Journal of toxicology and environmental health. Volume 82:Issue 5(2019)
• Page Start: 383
• Page End: 386
• Publication Date: 2019-03-04
• Subjects: Fatty acids -- endothelium -- vascular response -- air pollution; Toxicology -- Periodicals; Environmental health -- Periodicals; 615.90205
• DOI: 10.1080/15287394.2019.1603282
• Languages: English
• ISSNs: 1528-7394

Abstract

ABSTRACT: Diesel and biodiesel emissions exposures reduce vascular responsiveness in vivo, but the components of PM responsible for this effect are poorly understood. Fatty acids (FAs) represent a significant fraction of the compounds that make up organic combustion by-products, and may be involved in vascular responses following inhalation. It was hypothesized that vascular tissue exposed to a model FA might impair responses to vasoactive agonists ex vivo . Rat aortic rings were exposed to oleic acid or 12-hydroxy oleic acid and responses determined by myography. 12-Hydroxy oleic acid was found to significantly reduce endothelium-dependent vasodilation at sub-cytotoxic concentrations. This approach demonstrates the potential for FAs, especially oxidized forms, to play a role in the vascular responses observed following air pollution exposure.