Histopathological differences of experimental aneurysms treated with bare platinum, fibered, and bioactive coils. Issue 3 (4th May 2019)

• Record Type: Journal Article
• Authors: Usami, Yoko; Hirokawa, Naoki; Saitoh, Masato; Okuda, Hiroki; Someya, Masanori; Hasegawa, Tadashi; Takakuwa, Yasunari; Sakata, Koh-ichi
• Is Part Of: Minimally invasive therapy & allied technologies. Volume 28:Issue 3(2019)
• Page Start: 172
• Page End: 177
• Publication Date: 2019-05-04
• Subjects: Coil embolization -- fibered coil -- bioactive coil -- histopathological features; Endoscopy -- Periodicals; Interventional radiology -- Periodicals; Endoscopic surgery -- Periodicals; 617.05
• DOI: 10.1080/13645706.2018.1499532
• Languages: English
• ISSNs: 1364-5706

Abstract

Abstract: Purpose: To evaluate the histopathological features of experimental aneurysms embolized with bare platinum, fibered, and bioactive coils. Material and methods: Twelve experimental aneurysms were constructed in three swine. The aneurysms were divided into four groups and were embolized using a bare platinum coil alone (P group, n = 2), a bioactive coil alone (B group, n = 2), a combination of fibered and bare platinum coils (F/P group, n = 4) and a combination of fibered and bioactive coils (F/B group, n = 4). Histopathological data for all aneurysms recorded at 63 days were analyzed in terms of neointima formation, fibrosis, foreign-body giant-cell infiltration, and organization. Results: Fibrosis was significantly greater in group B compared with that in group F/P ( p = .02). Inflammation with foreign-body giant-cell infiltration was significantly greater in groups F/P and F/B compared with that in groups P and B ( p = .007). Conclusion: The present study revealed that the embolic effect of fibered coils was not a thrombus but instead was a foreign-body response in the chronic phase.