Visceral adiposity index is associated with increased urinary albumin excretion: A population-based study. Issue 3 (June 2019)

• Record Type: Journal Article
• Authors: Sun, Kan; Lin, Diaozhu; Li, Feng; Qi, Yiqin; Feng, Wanting; Ren, Meng; Yan, Li; Liu, Dan
• Is Part Of: Clinical nutrition. Volume 38:Issue 3(2019)
• Page Start: 1332
• Page End: 1338
• Publication Date: 2019-06
• Subjects: Visceral fat accumulation -- Visceral adiposity index -- Increased urinary albumin excretion -- Albuminuria -- Population-based study; BMI body-mass index -- WC waist circumference -- FPG fasting plasma glucose -- TG triglycerides -- TC total cholesterol -- HDL-C high-density lipoprotein cholesterol -- LDL-C low-density lipoprotein cholesterol -- ALT alanine aminotransferase -- AST aspartate aminotransferase -- γ-GGT γ-glutamyltransferase -- SBP systolic blood pressure -- DBP diastolic blood pressure -- MET-h/week metabolic equivalent hours per week -- eGFR estimated glomerular filtration rate -- ACR albumin-to-creatinine ratio -- VAI visceral adiposity index -- SD standard deviation -- OR odds ratios -- CI confidence intervals; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2018.05.025
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background: The effects of visceral fat accumulation on the renal damage have drawn much attention. We aimed to investigate the possible relationship between visceral adiposity and albuminuria. Methods: We included information from a population-based study in 9473 subjects aged 40 years or older. As a novel and valid indicator for visceral adipose function, visceral adiposity index (VAI) was determined by gender-specific equations and calculated using simple anthropometric and functional parameters. Increased urinary albumin excretion was defined as albumin-to-creatinine ratio (ACR) 30 mg/g or greater. Results: The prevalence rate of increased urinary albumin excretion was 6.6% in this population and gradually increased across VAI quartiles. Participants with higher VAI had elevated age, blood pressure, cholesterol, fasting insulin and decreased high density lipoprotein cholesterol and estimated glomerular filtration rate (eGFR) level. In multivariate logistic regression analysis, the adjusted odds ratios (ORs) of increased urinary albumin excretion for increasing VAI quartiles were 1.00 (reference), 1.29 (95% confidence intervals [CI] 0.94–1.76), 1.46 (95% CI 1.08–1.97) and 1.79 (95% CI 1.33–2.41). In subgroup analysis and after multiple adjustments, significant relation between VAI level and prevalent increased urinary albumin excretion was detected in women, younger subjects, non-obesity subjects, those without diabetes and those with eGFR ≥60 ml/min per 1.73 m 2 . Conclusion: Visceral fat accumulation evaluating by VAI is independently associated with increased urinary albumin excretion in middle-aged and elderly Chinese.