Is there a relationship between vitamin D nutritional status and metabolic syndrome in childhood acute lymphoblastic leukemia survivors? A PETALE study. (June 2019)

• Record Type: Journal Article
• Authors: Delvin, E.; Marcil, V.; Alos, N.; Laverdière, C.; Sinnett, D.; Krajinovic, M.; Bélanger, V.; Drouin, S.; Nyalendo, C.; Levy, E.
• Is Part Of: Clinical nutrition ESPEN. Volume 31(2019)
• Page Start: 28
• Page End: 32
• Publication Date: 2019-06
• Subjects: Acute lymphoblastic leukemia -- Vitamin D -- 25-hydroxyvitamin D3 -- Insulin resistance -- Metabolic syndrome -- Lipids; Nutritionally induced diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; 616.39005
• DOI: 10.1016/j.clnesp.2019.03.006
• Languages: English
• ISSNs: 2405-4577

Abstract

Summary: Background: Treatment of childhood acute lymphoblastic leukemia (cALL) has reached unprecedented success leading to survival rates reaching 90%. This is regrettably linked to increased risk of developing long-term health-related sequels into early adulthood. Objective: This study aims at assessing the relationship between the vitamin D status and metabolic biomarkers in PETALE, a well-characterized cohort of cALL survivors. Results: We demonstrate that 15.9% of the study participants exhibited 3 or more metabolic syndrome (MetS) risk factors. We also show a direct relationship between s25OHD3 and plasma HDL-Cholesterol concentrations in female but not male participants. Conclusion: Our data, from a metabolically well-described cohort, support a modest role for vitamin D in lipid metabolism in childhood leukemia survivors. The major outcome of this study is the strong association between HDL-Cholesterol concentration and s25OHD3 only in female subjects, thereby conveying vitamin D a gender-specific cardio-protective effect. cALL survivors represent a population at higher risk for secondary diseases. For this reason thorough nutritional evaluation, including vitamin D should be part of the regular follow-up.