Triterpenes with unusual modifications from the fruiting bodies of the medicinal fungus Irpex lacteus. (June 2019)

• Record Type: Journal Article
• Authors: Tang, Yang; Zhao, Zhen-Zhu; Feng, Tao; Li, Zheng-Hui; Chen, He-Ping; Liu, Ji-Kai
• Is Part Of: Phytochemistry. Volume 162(2019)
• Page Start: 21
• Page End: 28
• Publication Date: 2019-06
• Subjects: Irpex lacteus (Fr.) Fr. -- Phanerochaetaceae -- Eburicane -- 19(10 → 5)abeo-eburicane -- Lanostane -- Triterpenoids -- Cytotoxicity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2019.02.017
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Ten previously undescribed triterpenoid congeners, namely irpeksolactins A–J, together with eighteen known ones, were isolated from the fruiting bodies of the rainforest-dwelling medicinal fungus Irpex lacteus . The structures of all the isolates were characterized by extensive spectroscopic approaches, including 1D & 2D NMR and MS spectroscopic methods. Irpeksolactin J displayed selective and weak cytotoxicity against the human lung cancer cell line A549 and the human hepatocellular carcinoma cell line SMMC-7721. Graphical abstract: Image 1 Highlights: Twenty-eight triterpenes are reported from Irpex lacteus. Irpeksolactin A is featured by a rare 19 (10. → 5) abeo -eburicane skeleton. Irpeksolactins F and G are featured by a rare 5, 8-peroxy bridge. Irpeksolactin J is featured by a rare 16, 24-epoxy group. Irpeksolactin J shows weak cytotoxicity.