Case report: Intraoperative thrombosis cardiac arrest in extended right hepatectomy involving use of local haemostatic agent in intraoperative cell salvage (ICS) and administration of recombinant activated factor VII (rFVIIa). (2019)

• Record Type: Journal Article
• Authors: Kyang, Lee S.; Howard, Andrew; Alzahrani, Nayef A.; Morris, David L.
• Is Part Of: International journal of surgery case reports. Volume 57(2019)
• Page Start: 48
• Page End: 51
• Publication Date: 2019
• Subjects: Mortality -- Recombinant activated factor VII -- Intraoperative cell salvage -- Thrombosis -- Liver resection -- rFVIIa; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2019.02.042
• Languages: English
• ISSNs: 2210-2612

Abstract

Highlights: Intractable intraoperative haemorrhage is a result of both surgical and coagulopathic (nonsurgical) components. There is increasing off-label use of rFVIIa for ceasing refractory bleeding aside from its application in patient with haemophilia. rFVIIa use may be associated with increased thromboembolic events according to some literature. The use of topical haemostatic agent in conjunction with ICS may potentially lead to systemic clot formation upon re-infusion of the chemical. Avoid use of cell saver suction while the surgical field is contaminated with topical clotting factors before irrigation with 0.9% sodium chloride. Abstract: Introduction: In modern surgical era, local haemostatic agents and blood components such as recombinant activated factor VII (rFVIIa) have expanded surgeons' armamentarium in controlling "surgical" and "nonsurgical bleeding". We report a case of intraoperative thrombosis and cardiac arrest involving use of local haemostatic agent in intraoperative cell salvage and rFVIIa administration in extended right hepatectomy. Presentation of case: A 46-year-old lady underwent extended right hepatectomy using cardiopulmonary bypass (CPB) and autotransfusion with ICS for metastatic gastrointestinal stromal tumour. She became extremely coagulopathic following weaning of CPB despite an array of fluid and blood products replacements. Decision to administer rFVIIa as a measure to arrest bleeding was unsuccessful. Extensive systemic thrombosis occurred which resulted in cardiac arrest and mortality. Discussion: The thromboembolic event was unclear but likely multifactorial. Two important hypotheses were the administration of rFVIIa and use of local haemostatic agent in ICS. Conclusion: Reported incidence of thromboembolism with use of rFVIIa in refractory bleeding is variable. More randomised controlled trials are needed to ascertain the efficacy and safety profile of the haemostatic agent. At present, off-label use of rFVIIa should be guided by the risk:benefit profile on a case-to-case basis. The authors also feel strongly against the use of local haemostatic gel in conjunction with ICS due to potential systemic circulation of the thrombin.