Focus on the pedunculopontine nucleus. Consensus review from the May 2018 brainstem society meeting in Washington, DC, USA. Issue 6 (June 2019)

• Record Type: Journal Article
• Authors: Garcia-Rill, E.; Saper, C.B.; Rye, David B.; Kofler, M.; Nonnekes, J.; Lozano, A.; Valls-Solé, J.; Hallett, M.
• Is Part Of: Clinical neurophysiology. Volume 130:Issue 6(2019:Jun.)
• Page Start: 925
• Page End: 940
• Publication Date: 2019-06
• Subjects: Arousal -- Basal ganglia -- Blink reflex -- Brainstem -- Calcium channels -- CaMKII -- cAMP -- Gait -- Gamma activity -- N-type -- P/Q-type -- Posture -- Prepulse inhibition -- Sleep -- Startle reflex; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2019.03.008
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Good evidence relates the pedunculopontine nucleus (PPN) to control of reflex reactions, sleep-wake cycles, posture and gait. The PPN has become a target for deep brain stimulation for the treatment of Parkinson's disease. This review is intended to provide a framework for future research. Abstract: The pedunculopontine nucleus (PPN) is located in the mesopontine tegmentum and is best delimited by a group of large cholinergic neurons adjacent to the decussation of the superior cerebellar peduncle. This part of the brain, populated by many other neuronal groups, is a crossroads for many important functions. Good evidence relates the PPN to control of reflex reactions, sleep-wake cycles, posture and gait. However, the precise role of the PPN in all these functions has been controversial and there still are uncertainties in the functional anatomy and physiology of the nucleus. It is difficult to grasp the extent of the influence of the PPN, not only because of its varied functions and projections, but also because of the controversies arising from them. One controversy is its relationship to the mesencephalic locomotor region (MLR). In this regard, the PPN has become a new target for deep brain stimulation (DBS) for the treatment of parkinsonian gait disorders, including freezing of gait. This review is intended to indicate what is currently known, shed some light on the controversies that have arisen, and to provide a framework for future research.