RIFM fragrance ingredient safety assessment, isophytol, CAS Registry Number 505-32-8. (October 2015)

• Record Type: Journal Article
• Authors: Api, A.M.; Belsito, D.; Bhatia, S.; Bruze, M.; Calow, P.; Dagli, M.L.; Dekant, W.; Fryer, A.D.; Kromidas, L.; La Cava, S.; Lalko, J.F.; Lapczynski, A.; Liebler, D.C.; Politano, V.T.; Ritacco, G.; Salvito, D.; Schultz, T.W.; Shen, J.; Sipes, I.G.; Wall, B.; Wilcox, D.K.
• Is Part Of: Food and chemical toxicology. Volume 84(2015)Supplement
• Page Start: S42
• Page End: S49
• Publication Date: 2015-10
• Subjects: Genotoxicity -- Repeated dose toxicity/developmental and reproductive toxicity -- Skin sensitization -- Phototoxicity/photoallergenicity -- Local respiratory toxicity -- Environmental toxicity; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2015.06.014
• Languages: English
• ISSNs: 0278-6915

Abstract

Highlights: Isophytol safety assessment based on RIFM's criteria. Safety assessment based on 7 Human health endpoints plus environmental. Repeated dose toxicity was determined to give the most conservative systemic derived NO[A]EL. An acceptable MOE was obtained.