Multiple keratin granulomata: A potential histologic clue to cutaneous squamous cell carcinoma responding to programmed cell death protein 1 inhibitor therapy. (4th April 2019)

• Record Type: Journal Article
• Authors: Kahn, Benjamin J.; Parker, Douglas; Yushak, Melinda; Stoff, Benjamin; Blalock, Travis W.
• Is Part Of: Journal of cutaneous pathology. Volume 46:Number 6(2019)
• Page Start: 452
• Page End: 454
• Publication Date: 2019-04-04
• Subjects: histology -- immunomodulation -- squamous cell carcinoma -- tumor‐infiltrating lymphocytes; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.13447
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract : We present histologic features of a locally advanced cutaneous squamous cell carcinoma (cSCC) treated with the programmed cell death protein‐1 (PD‐1) antagonist, pembrolizumab, with a partial response. This contributes to a growing body of literature supporting the efficacy of pembrolizumab in treatment of surgically unresectable cSCC. We also provide a detailed description of the histologic features, particularly keratin granulomata with adjacent lymphocytic aggregates and fibrosis, observed in cSCC under treatment with a PD‐1 antagonist.