Regulation of Th17 cells by P. UF1 against systemic Listeria monocytogenes infection. (4th May 2018)

• Record Type: Journal Article
• Authors: Colliou, Natacha; Ge, Yong; Gong, Minghao; Zadeh, Mojgan; Li, Jing; Alonzo, Francis; Mohamadzadeh, Mansour
• Is Part Of: Gut microbes. Volume 9:Isuse 3(2018)
• Page Start: 279
• Page End: 287
• Publication Date: 2018-05-04
• Subjects: P. UF1 bacterium -- Listeria monocytogenes -- SIGNR1 -- Th17 cells -- Th1 cells -- regulatory T cells -- mucosal immunity; Gastrointestinal system -- Microbiology -- Periodicals; Microbiology -- Periodicals; Intestine, Small -- Periodicals; 616.3
• DOI: 10.1080/19490976.2017.1417731
• Languages: English
• ISSNs: 1949-0984

Abstract

ABSTRACT: Regulation of Th17 and Th1 cell responses against intracellular pathogens, including Listeria monocytogenes ( L. m ), is critical to limit inflammation-induced tissue damage. We recently demonstrated the ability of P. UF1 bacterium derived from the intestinal bacterial commensals of preterm infants fed human breast milk to significantly mitigate pathogen-induced inflammation limiting colonic tissue damage. Here we further elucidated the potential of P. UF1 to also regulate innate and T cells, particularly Th17 and Th1 cells, against systemic L. m infection. Data demonstrate that P. UF1 not only robustly regulated protective Th17 and Th1 cells, but also sustained regulatory T cells (Treg cells) resulting in accelerated L. m clearance. Together, regulation of pathogenic inflammation by a novel probiotic bacterium such as P. UF1 may illuminate a new strategy to specifically control Th17-Th1 cells via IL-10 + Treg cells to limit systemic tissue damage induced by intracellular pathogens, including L. m .