Microbiota Diversity in Human Colorectal Cancer Tissues Is Associated with Clinicopathological Features. (17th February 2019)

• Record Type: Journal Article
• Authors: Wu, Yaxin; Shi, Lei; Li, Qing; Wu, Jiao; Peng, Wei; Li, Huan; Chen, Kequan; Ren, Yixing; Fu, Xiangsheng
• Is Part Of: Nutrition and cancer. Volume 71:Number 2(2019)
• Page Start: 214
• Page End: 222
• Publication Date: 2019-02-17
• Subjects: Cancer -- Periodicals; Nutrition -- Periodicals; Cancer; Nutrition; Periodicals; 616.9940654
• DOI: 10.1080/01635581.2019.1578394
• Languages: English
• ISSNs: 0163-5581

Abstract

Abstract: Aim: Few evidences are available regarding the link between microbiota composition in the human colorectal cancer (CRC) tissues and the patients' clinicopathological features. Methods: Microbiota diversity in CRC tissues ( n = 30) were profiled and compared by high-throughput sequencing with clinicopathological features, including tumor location, differentiation degree, metastasis, and CRC patients' gender and age. Results: Many bacteria with significant difference in abundance were identified associated with these clinicopathological features ( P < 0.05). There was a significant difference in microbial composition between right colon cancers (RCa) vs. left colon cancers (LCa), RCa vs. rectal cancers ( P < 0.05). The amount of Fusobacteria was significantly higher in LCa, moderately and poorly differentiated cancers (MPD), and young patients (<60 years), compared to RCa, well differentiated cancers (WD) and elder patients (>60 years), respectively ( P < 0.05). Helicobacter spp. in RCa and MPD patients was significantly higher than in LCa and WD patients ( P < 0.05). Firmicutes in non-lymph node metastasis (LNM) patients was significantly lower than in LNM patients ( P < 0.05). Conclusion: The different microbiota composition in the CRCs was associated with patients' clinicopathological features, which could be a consequence of microflora diversity.