Oxidative stress, neurotoxicity, and non-specific immune responses in juvenile red sea bream, Pagrus major, exposed to different waterborne selenium concentrations. (September 2015)

• Record Type: Journal Article
• Authors: Kim, Jun-Hwan; Kang, Ju-Chan
• Is Part Of: Chemosphere. Volume 135(2015)
• Page Start: 46
• Page End: 52
• Publication Date: 2015-09
• Subjects: Pagrus major -- Selenium -- Oxidative stress -- Neurotoxicity -- Non-specific immune response; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2015.03.062
• Languages: English
• ISSNs: 0045-6535

Abstract

Highlights: The antioxidant enzymes of Pagrus major were considerably increase by Se exposure. The AChE activity was significantly inhibited by Se exposure. The significant changes were observed in non-specific immune parameters. Abstract: Juvenile Pagrus major (mean length 15.8 ± 1.6 cm, and mean weight 90.4 ± 4.7 g) were exposed for 4 weeks with waterborne selenium concentration (0, 50, 100, 200, and 400 μg L −1 ). In oxidative stress indicators, liver and gill superoxide dismutase (SOD) activity and glutathione S-transferase (GST) activity were markedly elevated after 4 weeks exposure. Similarly, glutathione (GSH) level in liver and gill was also increased in response to the highest Se exposure after 4 weeks exposure. In neurotoxicity, AChE activity was inhibited in brain and muscle tissues by waterborne Se exposure. In the non-specific immune responses, lysozyme activity of plasma and kidney was significantly increased by waterborne Se exposure. Peroxidase activity and anti-protease activity were decreased at high Se concentration. The results suggest that waterborne Se exposure can induce significant oxidative stress, inhibition of AChE activity, and immunological alterations.