Focused transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex modulates specific domains of self-regulation. (February 2015)

• Record Type: Journal Article
• Authors: Pripfl, Jürgen; Lamm, Claus
• Is Part Of: Neuroscience research. Volume 91(2015:Feb.)
• Page Start: 41
• Page End: 47
• Publication Date: 2015-02
• Subjects: ANOVA analysis of variance -- CCAPAT Cue induced Craving and Affective Picture Appraisal Task -- dlPFC dorsolateral prefrontal cortex -- EEG electroencephalography -- FTND Fagerström Test for Nicotine Dependence -- IAPS International Affective Picture System -- PFC prefrontal cortex -- SAM Self-Assessment Manikin; Transcranial direct current stimulation -- Affective picture appraisal -- Cigarette craving -- Self-regulation -- Dorsolateral prefrontal cortex -- Cognitive control; Neurosciences -- Research -- Periodicals; Neurosciences -- Research -- Japan -- Periodicals; Neurology -- Periodicals; Neurosciences -- Periodicals; Neurosciences -- Recherche -- Périodiques; Neurosciences -- Recherche -- Japon -- Périodiques; Neurosciences -- Research; Japan; Periodicals; 612.8
• DOI: 10.1016/j.neures.2014.09.007
• Languages: English
• ISSNs: 0168-0102

Abstract

Highlights: We assess effects of focused tDCS of the dlPFC on different self-regulation domains. Focused tDCS over the right dlPFC reduces negative affect in emotion appraisal. Focused tDCS over the right dlPFC has no effect on appetitive appraisal. Focused tDCS over the left dlPFC has no effect on either self-regulation domain. Domain specific self-regulation networks are at work in the PFC. Abstract: Recent neuroscience theories suggest that different kinds of self-regulation may share a common psychobiological mechanism. However, empirical evidence for a domain general self-regulation mechanism is scarce. The aim of this study was to investigate whether focused anodal transcranial direct current stimulation (tDCS), facilitating the activity of the dorsolateral prefrontal cortex (dlPFC), acts on a domain general self-regulation mechanism and thus modulates both affective and appetitive self-regulation. Twenty smokers participated in this within-subject sham controlled study. Effects of anodal left, anodal right and sham tDCS over the dlPFC on affective picture appraisal and nicotine craving-cue appraisal were assessed. Anodal right tDCS over the dlPFC reduced negative affect in emotion appraisal, but neither modulated regulation of positive emotion appraisal nor of craving appraisal. Anodal left stimulation did not induce any significant effects. The results of our study show that domain specific self-regulation networks are at work in the prefrontal cortex. Focused tDCS modulation of this specific self-regulation network could probably be used during the first phase of nicotine abstinence, during which negative affect might easily result in relapse. These findings have implications for neuroscience models of self-regulation and are of relevance for the development of brain stimulation based treatment methods for neuropsychiatric disorders associated with self-regulation deficits.