High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: The ARCADIA-POL study. (April 2019)

• Record Type: Journal Article
• Authors: Talarowska, Paulina; Dobrowolski, Piotr; Klisiewicz, Anna; Kostera-Pruszczyk, Anna; Członkowska, Anna; Kurkowska-Jastrzębska, Iwona; Gąsecki, Dariusz; Warchoł-Celińska, Ewa; Światłowski, Łukasz; Florczak, Elżbieta; Januszewicz, Magdalena; Michałowska, Ilona; Józwik-Plebanek, Katarzyna; Szczudlik, Piotr; Błażejewska-Hyżorek, Beata; Protasiewicz, Marcin; Odrowąż-Pieniążek, Piotr; Tekieli, Łukasz; Michel-Rowicka, Katarzyna; Hanus, Katarzyna; Widecka, Krystyna; Sołtysiak, Marta; Tykarski, Andrzej; Stryczyński, Łukasz; Szczerbo-Trojanowska, Małgorzata; Hoffman, Piotr; Prejbisz, Aleksander; Januszewicz, Andrzej
• Is Part Of: Vascular medicine. Volume 24:Number 2(2019)
• Page Start: 112
• Page End: 119
• Publication Date: 2019-04
• Subjects: cerebrovascular disease -- fibromuscular dysplasia (FMD) -- hypertension -- cervical artery dissection; Blood-vessels -- Diseases -- Periodicals; Peripheral vascular diseases -- Periodicals; Vascular Diseases -- Periodicals; Vaisseaux sanguins -- Maladies -- Périodiques; Maladies vasculaires périphériques -- Périodiques; 616.13
• DOI: 10.1177/1358863X18811596
• Languages: English
• ISSNs: 1358-863X

Abstract

The association between fibromuscular dysplasia (FMD) and spontaneous cervical artery dissection (SCeAD) has been recognized, but the available evidence on this relationship is scant. Therefore, the main goal of our study was to systematically evaluate FMD frequency, clinical characteristics and vascular bed involvement in patients with SCeAD. Among 230 patients referred to the ARCADIA-POL study, 43 patients (mean age 44.1 ± 8.9 years; 15 men and 28 women) with SCeAD were referred. Also, 135 patients with FMD were compared to patients with and without SCeAD. Patients underwent: ambulatory blood pressure measurements, biochemical evaluation, echocardiographic examination, and whole body computed tomographic angiography. FMD changes were found in 39.5% of patients with SCeAD. There were no differences in clinical characteristics between patients with SCeAD and FMD and those without FMD, except for a tendency towards a higher female ratio in SCeAD patients with FMD. There were no differences in other parameters describing target organ and SCeAD characteristics. Patients with SCeAD and FMD compared to those without SCeAD were characterized by a lower frequency of hypertension and a higher frequency of hyperlipidemia and history of contraceptive hormone use. Our study indicates a high incidence (39.5%) of FMD in subjects with SCeAD. Since there are no distinctive discriminating factors between patients with SCeAD and FMD and those without FMD, FMD should be suspected in all patients with SCeAD.