Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case–control study. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Miao, Limin; Wang, Lihua; Zhu, Longbiao; Du, Jiangbo; Zhu, Xun; Niu, Yuming; Wang, Ruixia; Hu, Zhibin; Chen, Ning; Shen, Hongbing; Ma, Hongxia
• Is Part Of: Chinese journal of cancer. Volume 35:Issue 1(2016)
• Page Start: 1
• Page End: 8
• Publication Date: 2016-12
• Subjects: Head and neck cancer -- microRNA -- Polymorphism -- Squamous cell carcinoma -- Susceptibility; Cancer -- Periodicals; 616.994005
• DOI: 10.1186/s40880-016-0136-9
• Languages: English
• ISSNs: 1944-446X

Abstract

Abstract Background MicroRNA (miRNA) polymorphisms may alter miRNA-related processes, and they likely contribute to cancer susceptibility. Various studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers; however, few studies have focused on head and neck squamous cell carcinoma (HNSCC) risk. This study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese population. Methods In this study, we genotyped five common single-nucleotide polymorphisms (SNPs) in several key miRNAs (miR -149 rs2292832, miR -146a rs2910164, miR -605 rs2043556, miR -608 rs4919510, andmiR -196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case–control study including 576 cases and 1552 controls, which were matched by age and sex in a Chinese population. Results The results revealed thatmiR -605 rs2043556 [dominant model: adjusted odds ratio (OR) 0.71, 95% confidence interval (CI) 0.58–0.88; additive model: adjusted OR 0.74, 95% CI 0.62–0.89] andmiR -196a2 rs11614913 (dominant model: adjusted OR 1.36, 95% CI 1.08–1.72; additive model: adjusted OR 1.28, 95% CI 1.10–1.48) were significantly associated with the risk of oral squamous cell carcinoma (OSCC). Furthermore, when these two loci were evaluated together based on the number of putative risk alleles (rs2043556 A and rs11614913 G), a significant locus-dosage effect was noted on the risk of OSCC (P trend < 0.001). However, no significant association was detected between the other three SNPs (miR -149 rs2292832, miR -146a rs2910164, andmiR -608 rs4919510) and HNSCC risk. Conclusion Our study provided the evidence thatmiR -605 rs2043556 andmiR -196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population.